How To Boost Immune System – Mushroom Forte



Looking to find out how to boost immune system with a well researched immune support supplement?  See published study on it below.

Mushroom Forte provides a synergistic blend of Maitake, Reishi and Shiitake mushroom for immune system support. It contains certified organic fruiting body extracts to maximise mushroom beta-glucans.

Suggested dosage: 3-6 tablets per day

Contents: 60 tablets

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See the published study below on this immune support supplement:

PLoS One. 2019; 14(11): e0224740.
Published online 2019 Nov 7. doi: 10.1371/journal.pone.0224740
PMCID: PMC6837746
PMID: 31697749
Synergistic immuno-modulatory activity in human macrophages of a medicinal mushroom formulation consisting of Reishi, Shiitake and Maitake
Brody Mallard, Investigation, Methodology, Writing – original draft, Writing – review & editing,1 David N. Leach, Conceptualization, Investigation, Methodology, Writing – original draft,2,3 Hans Wohlmuth, Conceptualization, Methodology, Writing – original draft, Writing – review & editing,2,3,4 and Joe Tiralongo, Conceptualization, Investigation, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing1,*
Jianhua Yu, Editor
Author information Article notes Copyright and License information Disclaimer
Associated Data
Supplementary Materials
Data Availability Statement
A key characteristic of mushroom polysaccharides that elicit an immunomodulatory response is that they are rich in β-glucans and low in α-glucans. In this study we analysed nine commercially available preparations from three mushroom species, Reishi (Ganoderma lucidum), Shiitake (Lentinula edodes) and Maitake (Grifola frondosa), for β- and α-glucan content. Based on β- and α-glucan content we selected three extracts to combine into a formula and evaluated the ability of the individual extracts and formula to impact on the expression of cytokines IL-1α, IL-6, IL-10 and TNF-α in human macrophages with and without LPS stimulation. The majority of mushroom extracts and the formula were found to be highly potent immuno-stimulators possessing EC50 values lower than 100 μg/mL. Interestingly the mushroom formula had lower EC50 values in TNF-α expression from LPS stimulated macrophages compared to the individual extracts, suggesting a potential synergistic effect of the mushroom formula. A response additivity graph and curve-shift analysis illustrated that indeed the mushroom formula exhibited an immuno-stimulatory synergistic effect on the expression of the majority of cytokines evaluated in both LPS stimulated and non-stimulated human macrophages, with IL-10 having an antagonistic response. This study represents the first report of a synergistic immuno-modulatory response in human macrophages elicited from a mushroom formula rationally derived from β- and α-glucan content.

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