Parkinsons Disease Early Onset Treatment London


Parkinsons Disease early onset treatment londonOur Parkinsons Disease early onset treatment London clinic focuses on the underlying issues and not just the symptoms.

One person in every 500 has Parkinsons (PD). That’s about 127,000 people in the UK.

Most people who get Parkinsons are aged 50 or over but younger people can get it too. Parkinsons disease is characterised by slow movement, muscular rigidity and resting tremor. In addition, depression, sleep disturbances and frequently dementia characterise this disease. The pathology of PD indicates a progressive loss of the dopamine neurons of the substantia nigra together with the presence of Lewy bodies and alpha-synuclein. More extensive brain degeneration also occurs, from the medulla oblongata to the cerebral cortex. Inflammation has also been associated with Parkinsons.

The development of Parkinsons has been proposed to be due to multiple genetic and neurotoxic events that produce oxidative damage and cell death. In the case of Parkinsons the relevant targets of toxic events are neuromelanin-containing dopaminergic neurons of the substantia nigra.

A case-control study indicated that multiple environmental factors and genetic background were statistically related risk factors for the disease. Prominent among these were long-term toxic exposures and trauma early in life. For example, early life exposure to brain injury, chemicals and/or infections may initiate a cyclic inflammatory process involving oxidative damage, excitotoxicity, mitochondrial dysfunction and altered proteolysis that later in life results in substantia nigra neuron death.

A role for chronic infections in PD pathogenesis has been proposed. One infection found in PD that has aroused considerable interest is the presence of chronic gastrointestinal Helicobacter pylori. Indeed, treatment of this infection offers relief to late stage cachexia in PD patients receiving L-dopa. Helicobacter pylori-infected PD patients showed reduced L-dopa absorption and increased clinical disability, whereas treatment of this infection increased L-dopa absorption and decreased clinical disability. H. pylori may not be directly involved in the pathogenesis of PD, but its systemic presence could affect the progression and treatment of PD, probably by stimulating inflammation and autoimmunity.

Chronic infections in PD have been linked to inflammation and autoimmune responses. Experimental models of PD have been developed using neurological viral or bacterial infections to initiate the pathogenic process. Spirochetes have also been found in Lewy bodies of PD patients. Other infections, such as viral encephalitis, AIDS-associated opportunistic infections of the basal ganglia, coronavirus, among other infections, have been found in PD and could be important in stimulating inflammation and autoimmune responses.

It has been stressed that additional research will be necessary to establish whether a causal link exists between PD and chronic infections.

Our approach to Parkinsons Disease early onset treatment is to carefully choose functional medicine tests and chronic infection tests for each patient and formulate a treatment plan based on the test results, using natural medicine to meet each patient’s unique needs.


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